|Molar mass||168.15 g-mol-1|
|State of aggregation||
synced and corrected by elderman — – for —
152-154 °C (monohydrate)
|SI units are used wherever possible and customary. Unless otherwise stated, the data given are valid for standard conditions.|
Homogentisic acid is an intermediate product of the degradation of the amino acids phenylalanine and tyrosine and is present as an anion(homogentisate) at physiological pH values. It is converted into 4-maleylacetoacetic acid by the enzyme homogentisate dioxygenase (EC 126.96.36.199):
Subsequently, acetoacetic acid and fumaric acid are formed from this, which can be fed into the citrate cycle.
In alkaptonuria, a metabolic disease, the enzyme is absent or not present in sufficient amounts. “Alkapton” is the oxidized, black-brown form of the homogentisate.
- Metabolic disorder